Sinovac to test Covid-19 vaccine candidate on teenagers, kids in China

Reuters Beijing | Updated on September 17, 2020

The trial has been approved by the Chinese regulator, company claims

Chinese vaccine maker Sinovac Biotech plans to start a clinical trial of its experimental coronavirus vaccine with children and adolescents later this month, widening its test on a shot that is already in the final stage of study with adults.

Finding a vaccine that works for the entire population, including younger people, could be crucial to preventing outbreaks of the virus — which has led to over 930,000 deaths worldwide — through schools and kindergartens, potentially affecting also teachers and parents.

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A total of 552 healthy participants aged between three and 17 will take two doses of US-listed Sinovac’s CoronaVac or a placebo in a combined Phase 1 and Phase 2 trial estimated to begin on September 28 in the northern Chinese province of Hebei, according to a registration record published on Wednesday.

The trial has already been approved by the Chinese regulator, a Sinovac spokesperson said.

China has inoculated at least tens of thousands of its citizens rolling out experimental coronavirus vaccines, attracting international interest in their development, despite expert concerns over the safety of drugs that have not completed standard testing.

Also read In Covid-19 vaccine race, China inoculates thousands before trials are completed

As part of that programme, CoronaVac, being tested in final-stage large-scale trials in Brazil, Indonesia and Turkey, has already been given to about 90 per cent of the company’s employees and their families.

Data so far suggests the virus generally causes milder disease in children compared with adults, but some cases of children requiring intensive care have been also reported, according to the World Health Organization.

Also read Is the race for a Covid-19 vaccine going a bit too fast?

Several hundred children were admitted to US hospitals with a rare but severe inflammatory syndrome, which could include symptoms such as fever, rashes and swollen glands, associated with the coronavirus.

Sinovac said earlier this month CoronaVac appeared to be safe and able to induce antibodies for older people, while the vaccine-generated antibody levels were slightly lower than seen in younger adults, citing preliminary results from an early to mid-stage trial.

Published on September 17, 2020

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