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The composition of microbes in the gut which changes dramatically during pregnancy can be beneficial to pregnant women, a new study has claimed.
Researchers from Cornell University found that although changes in the gut microbes are associated with metabolic disease under most circumstances, they could be beneficial in pregnant women.
“The findings suggest that our bodies have coevolved with the microbiota and may actually be using them as a tool-to help alter the mother’s metabolism to support the growth of the foetus,” Ruth Ley, senior study author, said.
“By the third trimester, the microbiota can induce changes in metabolism. In the context of pregnancy, these metabolic changes in the mother are healthy, because they promote energy storage in fat tissue and help support the foetus. Outside of pregnancy, however, these changes can lead to the development of type 2 diabetes and other health problems,” Ley said.
In non-pregnant animals, changes to gut microbe composition can cause symptoms of metabolic syndrome, including weight gain, abnormal glucose metabolism, and inflammation - an immune response that normally protects the body but can cause health problems.
Ley and her team obtained stool samples from 91 pregnant women. They found that gut microbes changed in composition from the first trimester to the third trimester, becoming less “normal” and less diverse over time.
Health-boosting bacteria decreased in abundance, while disease-related bacteria increased in number. In addition, signs of inflammation increased over the course of the pregnancy. “The changes in gut microbes were not related to diet, so we think the immune system or hormones play a role,” Ley said.
When gut microbes from pregnant women were transferred to healthy germ-free mice, animals that received microbes from the third trimester became fatter and had higher levels of inflammation markers and worse glucose metabolism than mice that received microbes from the first trimester.
The study was published in the journal Cell.
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