Packing batteries with more punch
Indian researchers are working on cells that can store more energy, last longer
Colorectal cancer is the third leading cause of cancer deaths worldwide. Dietary fibre and lifestyle changes have been recommended as measures for preventing colorectal cancer.
A team of researchers from Stem Cells and Regenerative Medicine Centre at the Yenepoya University, Karnataka has now found that high doses of water-soluble Vitamin C and niacin or Vitamin B3 can kill cancer stem cells.
In a study published in journal Cell Biology International, researchers have shown for the first time the opposing effects of the low and high dose of vitamin C and vitamin B3 on colon cancer stem cells isolated from certain colorectal carcinoma cell lines.
Research team lead by Dr Bipasha Bose and Dr Sudheer Shenoy investigated the effects of high doses and low doses of the two vitamins and found that low doses (dose range 5-25 micromolar) of Vitamin C and B3 lead to high proliferation and aggressiveness of colon cancer stem cells thereby indicating a need to be cautious while prescribing low doses of these vitamins to colon cancer patients.
However, high doses of the two vitamins (dose range 100 to 1000 micromolar) were successful in killing cancer stem cells. Such high doses of vitamins can only be achieved through intravenous injections in colon cancer patients.
“The next step of our research is to delineate the mechanisms involved in such opposing effects of low versus high concentrations of the two vitamins,” said Dr Bipasha Bose, a member of the research team. “We want to decipher the mechanisms of action of high doses of Niacin and Vitamin C involving PPARγ pathway and oxidative stress induced killing of colon cancer stem cells. We also want to establish the same dose effect of in-vitro studies under in vivo conditions in tumor xenografts models in mice.”
This work is of significance and researchers hope to establish a therapeutic dose of Vitamin C and B3 for colon cancer stem cell therapy. “If the therapeutic dose gets well validated under in vivo animal models, clinical trials can be a possibility in the long run,” added Dr Bose.
The research team included Dr. Sudheer Shenoy, Dr. Bipasha Bose, Utsav Sen, Debajit Chaudhury and Muhammad Nihad.
Twitter: @Yogesh21sharma9
(India Science Wire)
Indian researchers are working on cells that can store more energy, last longer
To fix a broken bone, doctors often harvest another bone from the patient’s body or from someone else. It ...
Superconductors from IIScScientists at IISc Bangalore have invented a device with a nanocrystal structure ...
Engineering and construction giant L&T has won a licence from the Council of Scientific & Industrial ...
Ensure that the investment thesis based on which you bought the IPO still holds good
Digital money-lending platforms may be hassle-free and convenient, but look before you leap
Both the Nifty 50 and the Sensex continue to record new highs, but stay alert
Care Health Insurance’s new rider offers no great benefit. We review its pros and cons
India is ready with two vaccines to beat the deadliest virus of recent times. The immunisation drive, however, ...
Sopan Deb’s journey towards personal catharsis is perhaps the most honest and straightforward look a man can ...
A crackling fire, a tusker and a family scandal bring together a group of fellow travellers in Kerala
Although they match their Gujarati, South Indian and North Indian counterparts bite for bite, Maharashtrian ...
Digital is becoming dominant media, but are companies and their ad agencies transforming fast enough to make a ...
Slow Network, promoted by journalist-lyricist Neelesh Misra, pushes rural products and experiences
How marketers can use the traditional exchange of festive wishes meaningfully
For Fortune, a brand celebrating its 20th anniversary, it was a rude shock to become the butt of social media ...
Three years after its inception, compliance with GST procedures remains a headache for exporters, job workers ...
Corporate social responsibility (CSR) initiatives of companies are altering the prospects for wooden toys of ...
Aequs Aerospace to create space for large-scale manufacture of toys at Koppal
And it has every reason to smile. Covid-19 has triggered a consumer shift towards branded products as ...
Please Email the Editor