Click chemistry . Nobel prize in chemistry awarded to three scientists who made molecules 'click'

Three scientists from the United States and Denmark were jointly awarded this year's Nobel Prize in chemistry for developing a way of “snapping molecules together” that can be used to design better medicines.

Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless were cited for their work on click chemistry and bioorthogonal reactions, which are used to make cancer drugs, map DNA and create materials that are tailored to a specific purpose.

“It's all about snapping molecules together,” said Johan Aqvist, a member of the Royal Swedish Academy of Sciences that announced the winners Wednesday at the Karolinska Institute in Stockholm, Sweden.

Sharpless, who previously won a Nobel Prize in 2001 and is now the fifth person to receive the award twice, first proposed the idea for connecting molecules using chemical “buckles” around the turn of the millennium, said Aqvist.

“The problem was to find good chemical buckles,” he said. “They have to react with each other easily and specifically.”

Meldal, based at the University of Copenhagen, Denmark, and Sharpless, who is affiliated with Scripps Research, California, independently found the first such candidates that would easily snap together with each other but not with other molecules, leading to applications in the manufacture of medicines and polymers.

Bertozzi, who is based at Stanford University in California, “took click chemistry to a new level,” the Nobel panel said.

She found a way to make click chemistry work inside living organisms without disrupting them, establishing a new method known as bioorthogonal reactions. Such reactions are now used to explore cells, track biological processes and design experimental cancer drugs that work in a more targeted fashion.

Bertozzi said she was “absolutely stunned” to receive the prize.

A week of Nobel Prize announcements kicked off Monday with Swedish scientist Svante Paabo receiving the award in medicine for unlocking secrets of Neanderthal DNA that provided key insights into our immune system. Three scientists jointly won the prize in physics Tuesday.

The awards continue with literature on Thursday. The 2022 Nobel Peace Prize will be announced on Friday and the economics award on Monday.

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